Dr. Wylie's research is primarily focused on equity and cultural safety in health services delivery. Her applied approach includes supporting the development of interdisciplinary multi-sector models of service coordination that can improve continuity of care. Her current projects examine access to and experiences with health care services for Indigenous peoples and immigrant/ refugee populations. She also focuses on cultural competency of health care providers and institutions. In addition, she examines governance and models of care among First Nations controlled health services. Her work also examines the effectiveness of educational initiatives in changing health care practices, through community based evaluation.